Janet S. Anderson
Janet S. Anderson
Florence B. Sherwood Professor of Physical Sciences
Professor of Chemistry
Office: WOLD 221
Phone: (518) 388-6252
Email: andersoj@union.edu
Education Courses Research Links
Education:

B.S. Chemistry, College of William and Mary , 1972
Ph.D. Physical Chemistry, University of Wisconsin-Madison, 1976
Postdoctoral Research. Protein Computational Chemistry, Cornell University, 1976-1978

Courses:

CHM  60 Meals to Molecules
CHM 101 Introductory Chemistry I
CHM 101 Lab
CHM 102 Introductory Chemistry II
CHM 102 Lab

CHM 110 Accelerated Introductory Chemistry
CHM 351 (Kinetics and Thermodynamics)
CHM 352 (Quantum Chemistry)
CHM 354 (Chemical Applications of Group Theory)

 

Research Interests:

In collaboration with Griselda Hernãndez and David LeMaster at the Wadsworth Center, New York State Department of Health, Albany, NY, my students and I use NMR data to investigate the structure and dynamics of proteins.

I am interested in using Mathematica in Physical Chemistry courses, and in the integration of molecular modeling into all areas of the chemistry curriculum.

Recent Publications and Presentations:
 LeMaster, David M.; Anderson, Janet S.; Hernández, Griselda (2007) "Normal carbon acid referencing for protein amide hydrogen exchange " Magnetic Resonance in Chemistry 45, 601-604.


LeMaster, David M.; Anderson, Janet S.; Hernández, Griselda (2007) "Spacial Distribution of Dielectric Shielding in the Interior of Pyrococcus furiosus Rubredoxin as Sampled in the Subnanosecond Timeframe by Hydrogen Exchange", Biophysical Chemistry 129, 43-48.

Hernández, Griselda, Anderson, Janet S., and LeMaster, David M. (2008) "Electrostatic Stabilization and General Base Catalysis in the Active Site of the Human Protein Disulfide Isomerase a Domain Monitored by Hydrogen Exchange", ChemBioChem 9, 768-778.

LeMaster, David M., Anderson, Janet S., Wang, Limin, Guo, Yi, Li, Hongmin and Hernández, Griselda (2008) "NMR and X-ray analysis of structural additivity in metal binding site-swapped hybrids of rubredoxin" BMC Structural Biology 7:81, doi:10.1186/1472-6807-7-81.

Anderson, Janet S.; Hernández, Griselda; LeMaster, David M. (2008) "A Billion-fold Range in Acidity for the Solvent-Exposed Amides of Pyrococcus furiosus Rubredoxin" Biochemistry 47, 6178-6188. 

 

Anderson, Janet S.; Hernández, Griselda; LeMaster, David M. (2009) "Backbone Conformational Dependence of Peptide Acidity", Biophysical Chemistry 141, 124-130.

 

Janet S. Anderson, Griselda Hernández, and David M. LeMaster, “Structural model dependence of protein peptide acidity predictions for surface-exposed amides”, presented at the Proteins Gordon Research Conference, Holderness School, NH, June, 2009.

 

Hernández, Griselda; Anderson, Janet S.; LeMaster, David M. (2009) "Polarization and Polarizability Assessed by Protein Amide Acidity", Biochemistry 48, 6482-6494.

 

LeMaster, David M.; Anderson, Janet S.; Hernández, Griselda (2009) "Peptide Conformer Acidity Analysis of Protein Flexibility Monitored by Hydrogen Exchange", Biochemistry 48, 9256-9265.

 

Janet S. Anderson, Griselda Hernández, and David M. LeMaster, “Structural model dependence of protein peptide acidity predictions for surface-exposed amides”, poster presented at the Proteins Gordon Research Conference, Holderness School, NH, June, 2009

 

Anderson, Janet S.; Hernández, Griselda; LeMaster, David M. (2010) Conformational Electrostatics in the Stabilization of the Peptide Anion, Current Organic Chemistry 14, 162-180.

 

Anderson, Janet S.; Hernández, Griselda; LeMaster, David M. (2010) Sidechain conformational dependence of hydrogen exchange in model peptides, Biophysical Chemistry 151, 61-70.

 

Hernández, Griselda; Anderson, Janet S.; LeMaster, David M. (2010) Assessing the native state conformational distribution of ubiquitin by peptide acidity, Biophysical Chemistry 153, 70-82.

 

Janet S. Anderson, Griselda Hernández, and David M. LeMaster, “Sidechain conformational dependence of hydrogen exchange in model peptides”, poster presented at the 12th Annual Upstate NY NMR Symposium, SUNY Albany, Albany, NY, November 29, 2010.

 

Hernández, G., Anderson, J.S., and LeMaster, D.M. Electrostatics of Hydrogen Exchange for Analyzing Protein Flexibility. Invited chapter in Methods in Molecular Biology, 2011, Ed. Shektman, A. and Burz, D.S. (Humana Press), in press.

 

Janet S. Anderson, Griselda Hernández, and David M. LeMaster, “Cumulative Probability Distribution Analysis of Model Protein Ensembles as Assessed by Peptide Acidity”, poster presented at the Gordon Research Conference—Computational Aspects of Biomolecular NMR”, Il Ciocco, Italy, May, 2011.

 

Links:
  • The Protein Data Bank(PDB) is a repository for all solved protein structures. It gives coordinates for all atoms and other information about the protein structure.
  • Mathematica is a program which can do both symbolic and numerical mathematics, with entensive graphics capabilities.
  • Spartan uses quantum mechanical and semi-empirical methods to model small molecules.