Molecular Biology of he Cell (BIO 225), Cancer Cell Biology (BIO 378) and Senior Seminar (BIO 488)
Cell locomotion, cell adhesion and the cytoskeleton. I am currently investigating the relationship between contractility and organization of the cytoskeleton in living cells.
My research is focused on understanding crawling cell locomotion. More specifically, I am interested in how one set of cytoskeletal filaments, the microtubules, influences another cytoskeletal system, the actin microfilaments, during locomotion. The regulation of cell motility has important implications for the processes of would healing and cancer metastasis. Currently, I am investigating changes in microtubule post translational modifications in response to a variety of stimuli, including ATP depletion.
- Quinones, G.B., Danowski, B.A., Devaraj, A., Singh, V., and Ligon, L.A. (2011), The Post-translational Modification of Tubulin Undergoes a Switch from Detyrosination to Acetylation as Epithelial Cells become Polarized. Mol. Biol. Cell 22(7) 1045-1057.
- Yvon, A-M., Walker, J.W., Danowski, B.A., Fagerstrom, C., Khodjakov, A., Wadsworth, P. 2002, Centrosome Reorientation in Would Edge Cells is Cell Type Specific. Mol. Biol. Cell 13(6):1871-1880
- Danowski, B.A., Khodjakov, A., Wadsworth, P., 2001, Centrosome Behavior in Motile HGF-treated PtK2 Cells Expressing GFP-Gamma-Tubulin. Cell Motility and the Cytoskeleton 50:59-68.