May 17, 2019 12:50 PM–1:40 PM
Wold 128

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Sam Choi '17  (Department of Biomedical Engineering, University of Michigan)

Histotripsy is a form of ultrasound therapy where short, intense bursts of sound induce highly energetic
cavitation within tissue leading to disruption of structures and cell lysis. This method is showing promise
to be a viable non-invasive surgical technique for a wide variety of medical applications in the liver,
kidney, prostate, brain, and vasculature. While feasibility has been shown in both large and small animal
models for all these tissue targets, a number of challenges remain in translating this work to the clinic.
This talk will give an overview of the physics of histotripsy and current projects that will bring us closer
to translation and as a competitive option in the clinic. I will also discuss in detail my PhD project,
stereotactic histotripsy, that uses pre-treatment MR images to guide histotripsy tumor ablation on rodent
Glioblastoma models with sub-millimeter accuracy, and the challenges that followed.

Sang Won (Sam) Choi graduated from Union College in 2017 with a degree in Biomedical Engineering. Sam is currently in the PhD BME program at the University of Michigan, where he is a member of the Biomedical Ultrasonics Laboratory. Sam will present some of his exciting research in ultrasound surgery and share his experiences in the graduate school application process.