Chemistry Department
James Andrian Jr.

James C. Adrian Jr.

Job Title
Professor of Chemistry
ISEC 287

Areas of expertise

Organic Synthesis, Synthetic Methods; NMR interpretation, and Military Costume of the 14th Century.

Research interests

Organic Chemistry: Synthetic organic methods development

Teaching interests

CHM 231 Organic Chemistry I & Lab
CHM 232 Organic Chemistry II & Lab
CHM 332 Synthetic Methods


  • Publications
    • James C. Adrian, Jr., et. al. “The synthetic substance hypoxanthine 3-N-oxide elicits alarm reactions in zebrafish.” Behavioral Brain Research 2009, 205, 335-341.
    • Jocelyn M. Kelly, James C. Adrian, Jr., and Grant E. Brown “Can the ratio of aromatic skeletons explain cross-species responses within evolutionarily conserved Ostariophysan alarm cues?: testing the purine-ratio hypothesis.” Chemoecology 2005, 16, 93-96.
    • James C. Adrian, Jr “Multiple-Component Condensation Methods for the Preparation of Combinatorial Libraries of ß-Amino Carbonyl Derivatives” In Enantioselective Synthesis of ß-Amino Acids, 2nd Ed. John Wiley & Sons, Chapter 21, 2005, 497-525.
    • Avrum L. Joffe, Timothy M. Thomas and James C. Adrian, Jr “A stereoselective, multiple component approach to α–β-substituted-β-amino carbonyl derivatives” Tetrahedron Letters, 2004, 45, 5087-5090.
    • James C. Adrian, Jr., and Marc L. Snapper “Multiple Component Reactions: An Efficient Nickel Catalyzed Reformatisky-Type Reaction and its Application in the Parallel Synthesis of ß-Amino Carbonyl Libraries” Journal of Organic Chemistry, 2003, 68, 2143-2150.
    • James C. Adrian, Jr., Leslie A. Hull “The Oxidation of Alkylbenzenes: Using Data Pooling in the Organic Laboratory to Illustrate Research in Organic Chemistry” Journal of Chemical Education, 2001, 78, 529-530.
    • James C. Adrian, Jr., Julia L. Barkin, Richard J. Fox, Jennifer E. Chick, Allen D. Hunter, and Rhea A. Nicklow “Chlorotitanium Enolate Addition to Aldimines: A Stereoselective Route to α-Oxy-β-Substituted-β-Amino Esters.” Journal of Organic Chemistry, 2000, 65, 6264-6267.
    • Grant E. Brown, James C. Adrian, Jr., Erin Smyth, Heather Leet and Scott Brennan "Ostariophysan Alarm Pheromones: Laboratory and Field Tests of the Functional Significance of Nitrogen-Oxides." Journal of Chemical Ecology, 2000, 26, 139-154.
    • James C. Adrian, Jr., Julia L. Barkin and Lamyaa Hassib "ß-Amino Esters via the Reformatsky Reaction: Restraining Effects of the ortho-Methoxyphenyl Substituent." Tetrahedron Letters, 1999, 40, 2457-2460.
    • James C. Adrian, Jr., Lamyaa Hassib, Norbert De Kimpe, and Marian Keppens "A New Approach to Symmetric 2,2':6',2"-Terpyridines" Tetrahedron, 1998, 54, 2365-2370.

Academic credentials

B.S., University of Maryland; Ph.D., University of Pittsburgh; Postdoc, Yale University